Dual Role Research Articles

The Metabolism, Detrimental Effects, and Signal Transduction Mechanism of Reactive Oxygen Species in Plants under Abiotic Stress

Plants are a major source of bio based materials, and their productivity is significantly impacted by environmental adversities with the continuous deterioration of the environment. The disruption of reactive oxygen species (ROS) production and scavenging balance is a common consequence of various abiotic stresses in plants, resulting in the excessive accumulation of ROS. However, it is crucial to acknowledging the dual role of ROS, acting both as harmful substances and signaling molecules. ROS can interact with membrane proteins, initiating a chain reaction of membrane lipid peroxidation. This process leads to a decrease in membrane lipid unsaturation and fluidity, as well as an increase in membrane permeability. Inhibited enzyme activity even lead to loss of protein function, caused DNA damage and mutations, blocked DNA replication and transcription, eventually leading to cell death. This can result in significant reductions in crop yield and biomass in bio based agricultural production. ROS also played vital role in signal molecule transduction in the process of plant resistance to stress, and worked in concert with other signal molecules to induce the stress resistance genes’ expression and enhance plant resistance. Hereto, scavenging mechanism for ROS in plants is of the essence to regulate the concentration of ROS, thus determining which role ROS play. The thermal dissipation of excess light energy effectively avoids ROS production, and the enzymatic and non-enzymatic antioxidant defense systems in plants work cooperatively to clear excessive ROS. This review provides a comprehensive summary of the production pathway, detrimental effects, scavenging mechanism and signal transduction of ROS in plants under abiotic stress.

Numerical investigation into turbulent drag reduction via the application of pufferfish spine-inspired cone microstructures in Suboff models

The effective reduction of seawater drag is pivotal in enhancing the speed and minimizing the energy consumption of submarines, which has significant implications in the fields of energy and defense. Surface bionics has emerged as one of the leading techniques for drag reduction. Current research primarily focuses on replicating the groove-like structures observed on shark skins and the flexible properties of dolphin skins. However, the application of cone microstructures on submarine surfaces remains relatively underexplored. In this study, a novel arrangement of bionic drag-reducing microstructures is employed to modify the turbulence structure surrounding the submarine by incorporating bionic cone microstructures at both the front and rear ends of the submarine. Numerical simulations were performed using the SST k-ω turbulence model to evaluate the impact of these frontal microstructures on drag reduction under varying Reynolds numbers, spacings, and positions, as well as the tail microstructures’ effect at different Reynolds numbers, heights, and circumferential separation angles. The findings reveal that positioning microstructures at the submarine’s head increases the drag reduction rate proportionally with the distance from the apex, displaying an inverse relationship between spacing and drag reduction rate. Conversely, an increase in cone separation angle at the tail leads to a decrease in the overall drag reduction rate. At the same time, an inverse proportionality is observed between cone height and drag reduction rate. This suggests that cone microstructures play a dual role: mitigating friction drag greatly and augmenting pressure drag, thereby achieving overall drag reduction. Moreover, these cone microstructures disrupt eddy currents within the boundary layer surrounding the submarine, restraining the propagation of turbulent momentum transfer in both the head and tail regions. This research not only pioneers a novel drag reduction strategy for underwater vehicles but also sparks new avenues for their optimized surface design.

Cadmium-modified iron lead borate glasses for radiation protection

Using cadmium-modified iron lead borate glasses with formula 30 B2O3 – 40 PbO – 10 Na2O – (20 -x) Fe2O3 – x CdO where x ranges from 0 to 20 mol%, this work aims to investigate the structural, physical, elastic, and radiation-shielding properties of practical economic radiation shields. The X-ray diffraction patterns confirm the amorphous nature of the samples. The results of Fourier-transform infrared spectroscopy (FTIR) demonstrate the formation of robust B–O–Cd linkages and diborocadmium ([B2CdO8]2−) structures, as well as the conversion from [BO3] to [BO4] structural units with increased CdO and the presence of PbO and Na2O as modifiers. The CdO function also plays a dual role as a former and as a modifier. The FTIR analysis showed that the material's elasticity and the CdO oxide concentration were directly correlated, suggesting that the glass system becomes stiffer as the CdO concentration increases. The study explores the effectiveness of radiation shielding and demonstrates that CdO-rich samples have higher effective atomic numbers and attenuation qualities.

Dual role of alkoxyamine-functionalized lamellar materials in the synthesis of hybrid polymers

Alkoxyamine-functionalized polysilsesquioxane lamellar materials were used as fillers and radical polymerization initiator in the synthesis of nanocomposites. This work is divided into three parts: (i) the synthesis and the characterization of functionnalized-lamellae, (ii) the study of their delamination and (iii) the polymerization leading to the nanocomposites. The presence of covalently bonded siloxane filler reinforced the polystyrene. In addition, the EPR analysis showed that alkoxyamine groups were still present on the nanocomposite and could be homolyzed under thermal condition to enable further potential functionalisations.

Visible-Light-Mediated Synthesis of Thioesters Using Thiocarboxylic Acid as the Dual Reagent.

We have developed a visible-light-driven method for thioester synthesis that relies on the unique dual role of thiobenzoic acids as one-electron reducing agents and reactants leading to the formation of sulfur radical species. This synthetic process offers a wide scope, accommodating various thioacid and thiol substrates without the need for a photocatalyst.

New role of ionic liquid as accelerator activator in rubber compounds and its influence on curing and mechanical properties

AbstractThis study focuses on the effect of ionic liquids (ILs) on the cure characteristics and filler dispersion of natural rubber (NR) and styrene‐butadiene rubber (SBR) gum and filled compounds. The complexation of ionic liquid with zinc oxide (ZnO) increases the activity of ZnO and the cure rate together with improved filler dispersion. This has also increased the rubber filler interaction. Imidazolium and chloride based ionic liquids with different cationic groups were compared and characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, and differential scanning calorimetry to understand the thermal and chemical behavior of the compounds. Interestingly, it was found that the ionic liquid can act as an activator and is able to accelerate the vulcanization rate with improved rubber filler interaction. The complexes formed by IL‐Zn were shown to be much more reactive than Zn‐stearic acid complexes. The dispersion of carbon black in the NR and SBR compounds was studied by using Field Emission Scanning Electron Microscope and Transmission Electron Microscope and the results demonstrate that ILs could significantly improve the filler dispersion. Thus, this study has revealed the multifunctional role of ionic liquids in rubber compounds.Highlights This article describes the dual role of the ionic liquid (IL) in rubber compounds. It can act both as an accelerator‐activator as well as an efficient dispersing aid. The complexation of IL with zinc oxide (ZnO) plays a crucial role in enhancing the activity of ZnO. As a result, the physico‐mechanical properties of both natural rubber and styrene‐butadiene rubber based compounds are significantly improved.

TCF21: A transcription factor that plays an important role in cardiovascular disease.

According to the World Health Organisation's Health Report 2019, approximately 17.18 million people die from cardiovascular disease each year, accounting for more than 30% of all global deaths. Therefore, the occurrence of cardiovascular disease is still a global concern. The transcription factor 21 (TCF21) plays an important role in cardiovascular diseases. This article reviews the regulation mechanism of TCF21 expression and activity, and focuses on its important role in atherosclerosis, in order to contribute to the development of diagnosis and treatment of cardiovascular diseases. TCF21 is involved in the phenotypic regulation of vascular smooth muscle cells (VSMCs), promotes the proliferation and migration of VSMCs, and participates in the activation of inflammatory sequences. Increased proliferation and migration of VSMCs can lead to neointimal hyperplasia after vascular injury. Abnormal hyperplasia of neointima and inflammation are one of the main features of atherosclerosis. Therefore, targeting TCF21 may become a potential treatment for relieving atherosclerosis. TCF21 as a member of basic helix-loop-helix transcription factors regulates cell growth and differentiation by modulating gene expression during the development of different organs and plays an important role in cardiovascular development and disease. VSMCs and cells derived from VSMCs constitute the majority of plaques in atherosclerosis. TCF21 plays a key role in regulation of VSMCs' phenotype, thus accelerating atherogenesis in the early stage. However, TCF21 enhances plaque stability in late-stage atherosclerosis. The dual role of TCF21 should be considered in the translational medicine.

Tourist Flows and Multi-Destination Trips: A Network Analysis

ABSTRACT Conventional approaches to modeling multi-destination trips are either based on trade-offs between one single destination and multiple destinations or on a sequence of destinations in a linear manner. These approaches are inadequate to capture the manifestation of multi-destination trips as a network at the aggregate level. Hence, built upon network analytical frameworks, this study adopted a directed network to model multi-destination trips. Using a visitor profile survey of Hong Kong, we found that the networks of multi-destination trips for both leisure and business travelers have several interesting properties, such as high densities, high clustering coefficients, and short diameters. High-degree nodes represent either destinations or origins in the leisure network, but they have a dual role as both destinations and origins in the business network. Network sparsity has a significant impact on the topology of the leisure network, but the impact is negligible on the business network.

Transposition of HOPPLA in siRNA-deficient plants suggests a limited effect of the environment on retrotransposon mobility in Brachypodium distachyon.

Long terminal repeat retrotransposons (LTR-RTs) are powerful mutagens regarded as a major source of genetic novelty and important drivers of evolution. Yet, the uncontrolled and potentially selfish proliferation of LTR-RTs can lead to deleterious mutations and genome instability, with large fitness costs for their host. While population genomics data suggest that an ongoing LTR-RT mobility is common in many species, the understanding of their dual role in evolution is limited. Here, we harness the genetic diversity of 320 sequenced natural accessions of the Mediterranean grass Brachypodium distachyon to characterize how genetic and environmental factors influence plant LTR-RT dynamics in the wild. When combining a coverage-based approach to estimate global LTR-RT copy number variations with mobilome-sequencing of nine accessions exposed to eight different stresses, we find little evidence for a major role of environmental factors in LTR-RT accumulations in B. distachyon natural accessions. Instead, we show that loss of RNA polymerase IV (Pol IV), which mediates RNA-directed DNA methylation in plants, results in high transcriptional and transpositional activities of RLC_BdisC024 (HOPPLA) LTR-RT family elements, and that these effects are not stress-specific. This work supports findings indicating an ongoing mobility in B. distachyon and reveals that host RNA-directed DNA methylation rather than environmental factors controls their mobility in this wild grass model.

How to deal with invasive species that have high economic value?

The ever-accelerating process of introduction and establishment of invasive alien species (IAS) in marine waters requires engaging different actors in the management and planning. To address this challenge, stakeholders need an integrated approach for defining actions of control and management within an ecosystem-based framework: to seek and enhance coordination, collaboration and trust among all stakeholders affected by changes in linked marine social - ecological systems. This study explores the complexities and opportunities in managing economically valuable IAS, demonstrating the need for tailored management strategies that consider key ecological details needed for successful control such as timing of removals and key economic considerations such as appropriate incentive mechanisms and time horizons in favor of long-term conservation goals. We propose a set of actions that can serve as a roadmap for effective IAS control and management, considering their dual role as nuisances and valuable resources. These actions pertain to local, regional and international levels, encouraging meaningful stakeholder engagement through co-management structures that can foster the development of robust management plans, enabling better IAS control. The outcome holds potential for positive contributions to the blue economy— sustainable use of marine resources, including fisheries, tourism, and renewable energy— and for meeting sustainability objectives.

Rapid alkalinization factor 22 has a structural and signalling role in root hair cell wall assembly.

Pressurized cells with strong walls make up the hydrostatic skeleton of plants. Assembly and expansion of such stressed walls depend on a family of secreted RAPID ALKALINIZATION FACTOR (RALF) peptides, which bind both a membrane receptor complex and wall-localized LEUCINE-RICH REPEAT EXTENSIN (LRXs) in a mutually exclusive way. Here we show that, in root hairs, the RALF22 peptide has a dual structural and signalling role in cell expansion. Together with LRX1, it directs the compaction of charged pectin polymers at the root hair tip into periodic circumferential rings. Free RALF22 induces the formation of a complex with LORELEI-LIKE-GPI-ANCHORED PROTEIN 1 and FERONIA, triggering adaptive cellular responses. These findings show how a peptide simultaneously functions as a structural component organizing cell wall architecture and as a feedback signalling molecule that regulates this process depending on its interaction partners. This mechanism may also underlie wall assembly and expansion in other plant cell types.

Sulfidation of nano-Fe/Pd bimetal for highly efficient remediation of Cr (VI) from water: Enhanced reactivity and applicability

Sulfidation of zero-valent iron nanoparticles (S-nZVI) has been considered as a common means to improve its reactivity. In this paper, Pd and Na2S were chosen as the catalyst and sulfidation regent via a modified post sulfidation approach to fabricate a kind of sulfidated bimetallic Fe/Pd nanoparticles (S-nZVIPd). The structure and composition have been clearly confirmed by a combination of various techniques. Morphology analysis showed that S-nZVIPd had a core–shell framework and hierarchical structure. The reactivity performance of S-nZVIPd, nZVIPd and S-nZVI toward Cr (VI) remediation from aqueous solution was compared, and the underlying mechanisms for the improvement effect of Cr (VI) removal were also investigated. S-nZVIPd exhibited a superior remediation reaction to remove Cr (VI) with higher removal capacity of 234.9 mg/g, with the comparison of nZVIPd (192.3 mg/g) and S-nZVI (137.5 mg/g). Additionally, the effects of common anions and cations, pH, and temperature on Cr (VI) removal were also investigated in batch experiments. Also, kinetic fitting of results revealed that remediation obeyed a pseudo-second-order model, where the apparent activation energy was 37.7 KJ/mol, illustrating that the removal of Cr (VI) was mainly dominated by chemical reduction. The enhanced removal rate of Cr (VI) by S-nZVIPd suggested that Pd and FeSx played a dual role in accelerating the corrosion of nZVI, and were facilitated to electron transfer between nZVI and Cr (VI). The results indicated that the research of the novel S-nZVIPd composite delivered new ideas theoretically for specific inquiries in the future.

An Investigation into the Larvicidal Activity of Biologically Synthesized Silver and Copper Oxide Nanoparticles Against Mosquito Larvae.

This study is primarily focused on the synthesis of silver and copper oxide nanoparticles utilizing the extract of Ipomoea staphylina plant and their larvicidal activity against specific larvae. Notably, Anopheles stephensi and Aedes aegypti are significant disease vectors responsible for transmitting diseases such as malaria, dengue fever, Zika virus, and chikungunya (Anopheles stephensi), and dengue and Zika (Aedes aegypti). These mosquitoes have a substantial impact on urban areas, influencing disease transmission dynamics. In an effort to control these larvae, we have pursued the synthesis of a herbal-based nanomedicine derived from I. staphylina, a valuable herb in traditional medicine. Our successful synthesis of silver and CuO nanoparticles followed environmentally sustainable green chemistry methodologies. The I. staphylina plant extract played a dual role as a reducing agent and dopant, aligning with principles of sustainability. We employed X-ray diffraction (XRD) analysis to validate the nanoparticle structure and size, while field-emission scanning electron microscopy (FE-SEM) revealed well-defined nanostructures. Elemental composition was determined through energy-dispersive X-ray (EDX) analysis, and UV-visible spectroscopy provided insights into the bandgap energy (3.15 eV for silver, 1.2 eV for CuO nanoparticles). These nanoparticles exhibited robust larvicidal activity, with CuO nanoparticles surpassing silver nanoparticles in terms of LC50 and LC90 values. Moreover, the developmental toxicity of CuO and Ag NPs was evaluated in zebrafish embryos as part of non-target eco-toxicological studies conducted in a standard laboratory environment. These findings underscore the potential utility of these nanoparticles as highly effective and environmentally friendly natural pesticides, offering cost-effectiveness and ecological benefits.

Surveying neurologist perspectives and knowledge of epilepsy surgery to identify barriers to surgery referral.

Epilepsy surgery is an effective means of treating medically refractory epilepsy (MRE), but it remains underused. We aimed to analyze the perspectives and knowledge of referring neurologists in the New York metropolitan area, who serve a large epilepsy population. We adapted a previous Canadian survey by Roberts etal. (2015), adding questions regarding demographic descriptors, insurance coverage, training and practice details, and perceived social barriers for patients. We surveyed neurologists directly affiliated with Montefiore Medical Center and those referring to Montefiore's Comprehensive Epilepsy Center. Participants had 10 weeks to fill out an online Qualtrics survey with weekly reminders. Of 117 neurologists contacted, 51 eligible neurologists completed the survey (63.8% Montefiore, 35.0% referring group). A high proportion of the results were from epilepsy-trained individuals (41.2%) and neurologists who graduated residency ≤19 years ago (80.4%). 80.4% of respondents felt that epilepsy surgery is safe, but only 56.9% would refer a patient for surgical workup after two failed trials of anti-seizure medications. Epileptologists and providers with a larger volume of epilepsy patients and electroencephalogram readings had better knowledge of the epilepsy surgery workup guidelines. When asked to rank social barriers to patients receiving surgery, participants were most concerned about lack of social support, financial insecurity, and a patient's dual role as a caregiver. Our study suggests continued reluctance of neurologists regarding epilepsy surgery, and deficiencies in the knowledge and adherence to the recommended guidelines. In the context of prior studies, these results showed improved understanding of the definition of MRE (80.4%) and an increased likelihood to refer eligible patients as early as possible (78.4%) in line with current consensus recommendations. The finding that epilepsy-trained and more epilepsy/electroencephalogram-facing neurologists showed better understanding of the guidelines suggests that increased education efforts should be targeted at non-epileptologists. Our study asked New York City doctors about their approach to epilepsy surgery. Many do not consider it as early as they could in treatment plans. The doctors with extra epilepsy training were better at knowing when to consider surgery.

Dual role of silt and clay in the formation and accrual of stabilized soil organic carbon

Soil organic carbon (SOC) is the largest terrestrial carbon (C) pool and is vulnerable to climate and land-use changes. Promoting the stabilization of SOC will reduce climate change-induced C losses. Mineral-associated organic carbon (MAOC), formed by the association of organic carbon with silt- and clay-sized minerals, is the major stabilized SOC fraction and key to sustaining soil health and mitigating climate change. However, the role of silt and clay in MAOC formation remains unclear in dryland ecosystems where microbes and plants are frequently under water stress. The current paradigm assumes that the main role of silt and clay is to adsorb and aggregate organic compounds. In a semi-arid environment, using a naturally occurring gradient of increasing soil silt and clay content partially due to aeolian dust inputs, we show that silt and clay also enhanced microbial decomposition of plant C inputs and microbial turnover, increasing microbial C inclusion into the MAOC pool. Finer-textured soils had higher soil water availability and higher volume of habitat available to microorganisms. The enhanced microbial processing interacted with changes in plant C inputs to further control the relative contribution of MAOC to SOC. Our results suggest SOC models should include soil textural effects on microbial activities and microbial C production in addition to physical protection of SOC. Our study also suggests that aeolian dust inputs can increase soil silt and clay contents and improve nutrient availability in dryland ecosystems, potentially mitigating the SOC loss under climate change and increasing the resilience of ecosystems to drought.

Visible Light-Induced One-Pot Carbonylation of Alkyl Halides with Aryl Formates.

Described herein is the development of a visible-light-driven carbonylation of alkyl halides. The exploitation of visible light to activate Pd complexes and the use of formates to serve the dual role of a CO surrogate and a phenoxide source allow the preparation of esters in moderate to good yields. Its relatively mild reaction conditions and the ability to perform this transformation without direct handling of toxic CO gas provide a practical means to access esters from alkyl halides.

CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus

Background and objectiveUnderstanding the regulation of efferocytosis by myeloid phagocytes is important in identifying novel targets in systemic lupus erythematosus (SLE). Cadherin-11 (CDH11), a cell adhesion molecule, is implicated in inflammatory arthritis and fibrosis and recently been shown to regulate macrophage phagocytosis. The extent and mechanism of this regulation is unknown. Our objective was to examine the extent to which CDH11 regulates myeloid phagocytes and contributes to autoimmunity and tissue inflammation. MethodsWe analyzed efferocytosis in macrophages and dendritic cells (DCs) from WT and Cdh11−/− mice and investigated the mechanisms in vitro. We investigated the role of CDH11 in disease development in vivo using the pristane induced lupus model. To translate the clinical relevance of CDH11 in human disease, we measured serum CDH11 levels in two independent pediatric SLE (pSLE) cohorts and healthy controls. ResultsUsing bone marrow derived macrophages (BMDMs) and DCs (BMDCs), we found impaired efferocytosis in phagocytes from Cdh11−/− mice, mediated by downregulated efferocytosis receptor expression and RhoGTPase activation. Specifically, loss of CDH11 downregulated Mertk expression and Rac1 activation in BMDMs, and integrin αVβ3 expression and Cdc42 activation in BMDCs, highlighting distinct pathways. In vivo, Cdh11−/− mice displayed defective efferocytosis and increased accumulation of apoptotic debris in pristane-induced lupus. Further, Cdh11−/− mice had enhanced systemic inflammation and autoimmune inflammation with increased anti-dsDNA autoantibodies, splenomegaly, type I interferons, and inflammatory cytokines. Paradoxically, at the tissue level, Cdh11−/− mice were protected against glomerulonephritis, indicating a dual role in murine lupus. Finally, SLE patients had increased serum CDH11 compared to controls. ConclusionThis study highlights a novel role of CDH11 in regulating myeloid cells and efferocytosis and its potential as a contributor to development in autoimmunity murine lupus. Despite the increase in autoimmunity, Cdh11−/− mice developed decreased tissue inflammation and damage.

Unfolding an Elusive Area-Selective Deposition Process: Atomic Layer Deposition of TiO2 and TiON on SiN vs SiO2.

Area-selective atomic layer deposition (AS-ALD) processes for TiO2 and TiON on SiN as the growth area vs SiO2 as the nongrowth area are demonstrated on patterns created by state-of-the-art 300 mm semiconductor wafer fabrication. The processes consist of an in situ CF4/N2 plasma etching step that has the dual role of removing the SiN native oxide and passivating the SiO2 surface with fluorinated species, thus rendering the latter surface less reactive toward titanium tetrachloride (TiCl4) precursor. Additionally, (dimethylamino)trimethylsilane was employed as a small molecule inhibitor (SMI) to further enhance the selectivity. Virtually perfect selectivity was obtained when combining the deposition process with intermittent CF4/N2 plasma-based back-etching steps, as demonstrated by scanning and transmission electron microscopy inspections. Application-compatible thicknesses of ∼8 and ∼5 nm were obtained for thermal ALD of TiO2 and plasma ALD of TiON.

Dwelling and healing with saints and jinn in the haunted landscapes of Palestine

The Jinn of Islamic and Middle Eastern popular mythology play a role in maintaining spatial divisions between sacred and profane space, public and protected areas, and acceptable and exceptional behaviour. Though research on jinn continues to be of importance in cross-cultural psychology, the rich relationship between jinn and place has largely been lost or severed. This paper seeks to restore this link through an examination of the relationship between unseen spirits and place in Palestine and throughout the Levant ( Bilad ash-Sham). Drawing upon both European and Palestinian historical ethnographic writing, as well as oral history interviews with Palestinian elders, this paper examines spatial practices that can attract, prevent, or heal harm from jinn and other unseen forces, as well as places where such spirits dwell, including graveyards, caves, wells, sacred trees, and shrines. Jinn play a dual role in helping to protect the sanctity of these places, while also threatening to violate the intimate space hearth and home. In this way, jinn play an important role in both establishing, and at times blurring and negotiating social mores and their related physical boundaries. In examining how jinn threaten the sanctity of homes and bodies, but also how place-dwelling spirits help to heal bodies and sooth souls, this paper moves beyond mere metaphorical understandings of spectral geographies to understand the material implications of unseen and imagined forces. By doing so, this paper builds upon recent research exploring the deep connection between the environment and spiritual/sacred understandings of place.

Development and Application of a New Exponential Model for Hydraulic Conductivity with Depth of Rock Mass

Hydraulic conductivity generally decreases with depth in the Earth’s crust. The hydraulic conductivity–depth relationship has been assessed through mathematical models, enabling predictions of hydraulic conductivity in depths beyond the reach of direct measurements. However, it is observed that beyond a certain depth, hydraulic conductivity tends to stabilize; this phenomenon cannot be effectively characterized by the previous models. Thus, these models may make inaccurate predictions at deeper depths. In this work, we introduce an innovative exponential model to effectively assess the conductivity–depth relationship, particularly addressing the stabilization at greater depths. This model, in comparison with an earlier power-like model, has been applied to a globally sourced dataset encompassing a range of lithologies and geological structures. Results reveal that the proposed exponential model outperforms the power-like model in correctly representing the stabilized conductivity, and it well captures the fast stabilization effect of multiple datasets. Further, the proposed model has been utilized to analyze three distinct groups of datasets, revealing how lithology, geological stabilization, and faults impact the conductivity–depth relationship. The hydraulic conductivity decays to the residual hydraulic conductivity in the order (fast to slow): metamorphic rocks, sandstones, igneous rock, mudstones. The mean hydraulic conductivity in stable regions is roughly an order of magnitude lower than unstable regions. The faults showcase a dual role in both promoting and inhibiting hydraulic conductivity. The new exponential model has been successfully applied to a dataset from a specific engineering site to make predictions, demonstrating its practical usage. In the future, this model may serve as a potential tool for groundwater management, geothermal energy collection, pollutant transport, and other engineering projects.